Package: PopComm
Title: Population-Level Cell-Cell Communication Analysis Tools
Version: 1.0.0
Authors@R: 
    c(person(given = "Zheng", family = "Gong", email = "gongzheng131@hotmail.com", role = c("aut", "cre"), 
    comment = c(ORCID = "0000-0001-7285-2630")),
    person(given = "Mengwei", family = "Li", email = "limengwei833@gmail.com", role = c("aut", "ctb"),
    comment = c(ORCID = "0000-0001-6163-2827")))
Description: Facilitates population-level analysis of ligand-receptor (LR) interactions 
    using large-scale single-cell transcriptomic data. Identifies significant LR pairs 
    and quantifies their interactions through correlation-based filtering and projection score 
    computations. Designed for large-sample single-cell studies, the package employs 
    statistical modeling, including linear regression, to investigate LR relationships 
    between cell types. It provides a systematic framework for understanding cell-cell 
    communication, uncovering regulatory interactions and signaling mechanisms. 
    Offers tools for LR pair-level, sample-level, and differential interaction analyses, 
    with comprehensive visualization support to aid biological interpretation. 
    The methodology is described in a manuscript currently under review and will be 
    referenced here once published or publicly available.
URL: https://github.com/JusticeGO/PopComm
BugReports: https://github.com/JusticeGO/PopComm/issues
biocViews:
Depends: R (>= 4.1.0)
Imports: Seurat (>= 4.1.0), broom (>= 1.0.0), dplyr (>= 1.0.0), purrr
        (>= 0.3.0), rlang, stringr (>= 1.4.0), tibble (>= 3.0.0), tidyr
        (>= 1.0.0), tidyselect (>= 1.1.0), Matrix (>= 1.2-0), ggplot2
        (>= 3.3.0), ggpubr (>= 0.6.0), pheatmap (>= 1.0.12),
        RColorBrewer, reshape2 (>= 1.4.1), scales (>= 1.1.1), igraph
        (>= 2.0.0), parallel, pbmcapply (>= 1.5.0), grDevices, cowplot
        (>= 1.1.1)
License: MIT + file LICENSE
Encoding: UTF-8
RoxygenNote: 7.2.3
LazyData: true
NeedsCompilation: no
Packaged: 2025-11-01 05:29:58 UTC; gongz
Author: Zheng Gong [aut, cre] (ORCID: <https://orcid.org/0000-0001-7285-2630>),
  Mengwei Li [aut, ctb] (ORCID: <https://orcid.org/0000-0001-6163-2827>)
Maintainer: Zheng Gong <gongzheng131@hotmail.com>
Repository: CRAN
Date/Publication: 2025-11-01 22:00:02 UTC
Built: R 4.5.3; ; 2026-08-10 05:52:35 UTC; windows
