Package: PFIM
Type: Package
Title: Population Fisher Information Matrix
Version: 8.0
Date: 2026-09-28
Authors@R: c(
    person(given = "Romain",
           family = "Leroux",
           role = c("aut"),
           comment = c(ORCID = "0009-0009-5779-5303"),
           email = "romain.leroux@inserm.fr"),
    person(given = "France",
           family = "Mentr\u00E9",
           role = c("cre"),
           comment = c(ORCID = "0000-0002-7045-1275"),
           email = "pfim@inserm.fr"),
    person(given = "Antoine",
           family = "Croxo",
           role = "ctb",
           comment = c(ORCID = "0009-0007-4726-5259"),
           email = "antoine.croxo@inserm.fr"),
    person(given = "Jérémy",
           family = "Seurat",
           role = "ctb",
           email = "jeremy.seurat@inserm.fr")) 
Maintainer: France Mentré <pfim@inserm.fr>
NeedsCompilation: yes
Description: Evaluate or optimize designs for nonlinear mixed effects models
    using the Fisher Information matrix. Supports population, individual, and
    Bayesian 'FIMs', covariates, inter-occasion variability, and D-optimal search
    ('Fedorov-Wynn', multiplicative, simplex, 'PSO', 'PGBO').
URL: http://www.pfim.biostat.fr/
Depends: R (>= 4.5.0)
SystemRequirements: C++17
License: GPL-3 | file LICENSE
Encoding: UTF-8
VignetteBuilder: knitr
Config/build/clean-inst-doc: FALSE
Imports: utils, Deriv, methods, deSolve, purrr, stringr, S7 (>= 0.2.0),
        Matrix, ggplot2 (>= 3.5.0), Rcpp, kableExtra, tibble, scales,
        stats, rmarkdown, rlang, knitr, tools, grDevices
Suggests: testthat (>= 3.2.3), withr
LinkingTo: Rcpp, RcppArmadillo
Config/testthat/edition: 3
Collate: 'CovariateModelEquation.R' 'Additive.R' 'Administration.R'
        'AdministrationConstraints.R' 'Fim.R' 'Model.R' 'Arm.R'
        'model-type-dispatch.R' 'pfim-project-access.R' 'PFIMProject.R'
        'pfim-fim-report-render.R' 'BayesianFim.R' 'Covariate.R'
        'CategoricalCovariate.R' 'CategoricalCovariateWithIOV.R'
        'ModelError.R' 'Combined1.R' 'Combined2.R' 'Constant.R'
        'Evaluation.R' 'CovariateTest.R' 'Design.R' 'Distribution.R'
        'Exponential.R' 'Optimization.R' 'FedorovWynnAlgorithm.R'
        'IndividualFim.R' 'LibraryOfModels.R' 'LibraryOfPDModels.R'
        'LibraryOfPKModels.R' 'LogNormal.R' 'ModelODE.R'
        'ModelAnalytic.R' 'ModelInfusion.R' 'ModelAnalyticInfusion.R'
        'ModelAnalyticInfusionSteadyState.R'
        'ModelAnalyticSteadyState.R' 'ModelODEInfusion.R'
        'ModelODEInfusionDoseInEquation.R' 'ModelParameter.R'
        'MultiplicativeAlgorithm.R' 'Normal.R' 'PFIM-package.R'
        'PGBOAlgorithm.R' 'PSOAlgorithm.R' 'PopulationFim.R'
        'Proportional.R' 'RcppExports.R' 'SamplingTimeConstraints.R'
        'SamplingTimes.R' 'SimplexAlgorithm.R' 'covariate-test-power.R'
        'covariates-fim-indbayes.R' 'covariates-fim.R'
        'evaluation-accessors.R' 'evaluation-plots.R'
        'evaluation-report-kable.R' 'evaluation-report.R'
        'model-analytic-eval.R' 'model-covariates.R'
        'model-error-variance.R' 'model-gradient.R'
        'model-library-remap.R' 'model-ode-bolus-simulate.R'
        'model-ode-bolus.R' 'model-variance.R' 'pfim-utils.R'
        'pfim-arm-constraints.R' 'pfim-constraint-grid.R'
        'pfim-constraints-helpers.R' 'pfim-continuous-opt.R'
        'pfim-errors.R' 'pfim-model-registry.R' 'pfim-registry.R'
        'pfim-extensions.R' 'pfim-fim-cache.R' 'pfim-fim-labels.R'
        'pfim-fim-optimal-arms.R' 'pfim-fim-optimizer-wiring.R'
        'pfim-flat-sampling-layout.R' 'pfim-gradient-perf.R'
        'pfim-linear-algebra.R' 'pfim-multi-design-opt.R'
        'pfim-plot-perf.R' 'pfim-rd-examples.R' 'pfim-session.R'
        'pfim-subject-fim.R' 'population-fim-variance.R'
        's7-reexports.R' 'zzz.R'
Config/roxygen2/version: 8.1.0
Packaged: 2026-09-28 13:20:43 UTC; MrLer
Author: Romain Leroux [aut] (ORCID: <https://orcid.org/0009-0009-5779-5303>),
  France Mentré [cre] (ORCID: <https://orcid.org/0000-0002-7045-1275>),
  Antoine Croxo [ctb] (ORCID: <https://orcid.org/0009-0007-4726-5259>),
  Jérémy Seurat [ctb]
Repository: CRAN
Date/Publication: 2026-09-28 14:50:21 UTC
