Package: simFastBOIN
Type: Package
Title: Fast Simulation of Bayesian Optimal Interval Designs for Phase I
        Trials
Version: 2.0.0
Date: 2026-09-18
Authors@R: person(given = "Gosuke",
                  family = "Homma",
                  role = c("aut", "cre"),
                  email = "my.name.is.gosuke@gmail.com",
                  comment = c(ORCID = "0000-0002-6854-5627"))
Description: Design and evaluate phase I dose-finding trials that use the
    Bayesian optimal interval (BOIN) design of Liu and Yuan (2015)
    <doi:10.1111/rssc.12089>. Functions are provided to tabulate the decision
    boundaries, to simulate trials, to estimate the dose-toxicity curve under a
    monotonicity constraint and to select the maximum tolerated dose. The
    simulation engine is written in C++ and draws one random variate per
    patient in enrollment order, which reproduces the reference implementation
    in the 'BOIN' package trial by trial for a given seed. The traditional 3+3
    design is provided as a comparator, with operating characteristics obtained
    in closed form rather than by simulation.
License: MIT + file LICENSE
Encoding: UTF-8
Depends: R (>= 3.5.0)
Imports: Rcpp (>= 1.0.0), stats, utils
LinkingTo: Rcpp
Suggests: BOIN, ggplot2 (>= 3.4.0), Iso, knitr, rmarkdown, spelling,
        testthat (>= 3.0.0)
Language: en-US
URL: https://github.com/gosukehommaEX/simFastBOIN
BugReports: https://github.com/gosukehommaEX/simFastBOIN/issues
Config/testthat/edition: 3
VignetteBuilder: knitr
Config/roxygen2/version: 8.0.0
NeedsCompilation: yes
Packaged: 2026-09-18 11:34:37 UTC; i_lik
Author: Gosuke Homma [aut, cre] (ORCID:
    <https://orcid.org/0000-0002-6854-5627>)
Maintainer: Gosuke Homma <my.name.is.gosuke@gmail.com>
Repository: CRAN
Date/Publication: 2026-09-18 15:00:13 UTC
