Used for the design and analysis of a 2x2 factorial trial for a time-to-event endpoint. It performs power calculations and significance testing as well as providing estimates of the relevant hazard ratios and the corresponding 95% confidence intervals. Important reference papers include Slud EV. (1994) <https://www.ncbi.nlm.nih.gov/pubmed/8086609> Lin DY, Gong J, Gallo P, Bunn PH, Couper D. (2016) <doi:10.1111/biom.12507> Leifer ES, Troendle JF, Kolecki A, Follmann DA. (2020) <https://github.com/EricSLeifer/factorial2x2/blob/master/Leifer%20et%20al.%20paper.pdf>.
| Version: | 0.2.0 | 
| Depends: | R (≥ 3.6.0), survival, stats, mvtnorm | 
| Suggests: | knitr, rmarkdown | 
| Published: | 2020-04-27 | 
| DOI: | 10.32614/CRAN.package.factorial2x2 | 
| Author: | Eric Leifer and James Troendle | 
| Maintainer: | Eric Leifer <Eric.Leifer at gmail.com> | 
| License: | GPL-2 | 
| NeedsCompilation: | no | 
| Materials: | README, NEWS | 
| CRAN checks: | factorial2x2 results | 
| Reference manual: | factorial2x2.html , factorial2x2.pdf | 
| Vignettes: | factorial2x2 (source, R code) | 
| Package source: | factorial2x2_0.2.0.tar.gz | 
| Windows binaries: | r-devel: factorial2x2_0.2.0.zip, r-release: factorial2x2_0.2.0.zip, r-oldrel: factorial2x2_0.2.0.zip | 
| macOS binaries: | r-release (arm64): factorial2x2_0.2.0.tgz, r-oldrel (arm64): factorial2x2_0.2.0.tgz, r-release (x86_64): factorial2x2_0.2.0.tgz, r-oldrel (x86_64): factorial2x2_0.2.0.tgz | 
| Old sources: | factorial2x2 archive | 
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