PFIM: Population Fisher Information Matrix

Evaluate or optimize designs for nonlinear mixed effects models using the Fisher Information matrix. Supports population, individual, and Bayesian 'FIMs', covariates, inter-occasion variability, and D-optimal search ('Fedorov-Wynn', multiplicative, simplex, 'PSO', 'PGBO').

Version:	8.0
Depends:	R (≥ 4.5.0)
Imports:	utils, Deriv, methods, deSolve, purrr, stringr, S7 (≥ 0.2.0), Matrix, ggplot2 (≥ 3.5.0), Rcpp, kableExtra, tibble, scales, stats, rmarkdown, rlang, knitr, tools, grDevices
LinkingTo:	Rcpp, RcppArmadillo
Suggests:	testthat (≥ 3.2.3), withr
Published:	2026-09-28
DOI:	10.32614/CRAN.package.PFIM
Author:	Romain Leroux [aut], France Mentré [cre], Antoine Croxo [ctb], Jérémy Seurat [ctb]
Maintainer:	France Mentré <pfim at inserm.fr>
License:	GPL-3 | file LICENSE
URL:	http://www.pfim.biostat.fr/
NeedsCompilation:	yes
SystemRequirements:	C++17
Citation:	PFIM citation info
Materials:	NEWS
In views:	Pharmacokinetics
CRAN checks:	PFIM results [issues need fixing before 2026-10-20]

Documentation:

Reference manual:	PFIM.html , PFIM.pdf
Vignettes:	Design evaluation and optimization in discrete space (source, R code) Design evaluation and optimization in continuous space (source, R code) Design evaluation and optimization with covariates — analytical PK model (source, R code) G-CSF PK-PD design evaluation (source, R code) Library of models (source, R code)

Downloads:

Package source:	PFIM_8.0.tar.gz
Windows binaries:	r-devel: PFIM_7.0.3.zip, r-release: PFIM_7.0.3.zip, r-oldrel: PFIM_7.0.3.zip
macOS binaries:	r-release (arm64): PFIM_7.0.3.tgz, r-oldrel (arm64): PFIM_7.0.3.tgz, r-release (x86_64): PFIM_8.0.tgz, r-oldrel (x86_64): PFIM_8.0.tgz
Old sources:	PFIM archive

Linking:

Please use the canonical form https://CRAN.R-project.org/package=PFIM to link to this page.